Abstract Background Approximately 30% of stroke cases result from carotid disease. Although several risk factors for complications after carotid endarterectomy have been identified, the existence of a biomarker that can estimate postoperative risk in these patients has not yet been proven. Objectives This study aimed to investigate correlations between the platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) and postoperative clinical outcomes in patients undergoing carotid endarterectomy. Methods A retrospective study was conducted, including 374 patients who underwent carotid endarterectomy between 2002 and 2019 due to moderate to high extracranial internal carotid artery stenosis. Their platelet-lymphocyte ratio and neutrophil-lymphocyte ratios were obtained from the same blood samples. Results There was a statistically significant correlation between the PLR and the occurrence of restenosis (p < 0.01) and acute myocardial infarction (AMI) after endarterectomy (p = 0.03). Additionally, there was a statistically significant correlation between the PLR and the combined outcomes stroke and/or AMI and/or death (p = 0.03) and stroke and/or AMI and/or death and/or restenosis (p < 0.01). However, there were no significant correlations between NLR and these outcomes (p = 0.05, p = 0.16). Conclusions The platelet-lymphocyte ratio proved to be a useful test for predicting occurrence of strokes, acute myocardial infarctions, and deaths during the postoperative period after carotid endarterectomy. It was also associated with the risk of postoperative restenosis.

Resumo Contexto Aproximadamente 30% dos casos de acidente vascular cerebral (AVC) resultam de doença carotídea. Embora vários fatores de risco para complicações pós-endarterectomia carotídea tenham sido identificados, ainda não foi comprovada a existência de um biomarcador que possa estimar o risco pós-operatório nesses pacientes. Objetivos Correlacionar o índice plaqueta-linfócito (IPL) e o índice neutrófilo-linfócito (INL) com os desfechos clínicos pós-operatórios em pacientes submetidos a endarterectomia carotídea. Métodos Estudo retrospectivo que incluiu 374 pacientes submetidos a endarterectomia carotídea, entre 2009 e 2019, por estenose extracraniana da artéria carótida interna. O IPL e o INL foram calculados, tendo sido obtidos das mesmas amostras de sangue. Resultados Houve correlação estatisticamente significativa entre IPL e presença de reestenose (p<0,01) e infarto agudo do miocárdio (IAM) após endarterectomia (p=0,03). Os desfechos combinados AVC e/ou IAM e/ou óbito e AVC e/ou IAM e/ou óbito e/ou reestenose apresentaram, respectivamente, correlação estatisticamente significativa com o IPL (p=0,03; p<0,01) e não significativa com o INL (p=0,05; p=0,16). Conclusões O IPL mostrou-se um teste útil, capaz de predizer os desfechos de AVC e/ou IAM e/ou óbito em pacientes no pós-operatório de endarterectomia carotídea, relacionando-se também com risco de reestenose pós-operatória.

RESUMO Durante o controle químico de insetos, doenças e plantas daninhas, dá-se muita importância ao produto fitossanitário e pouca atenção à técnica de aplicação. O controle de pragas da soja não escapa à regra geral e, dessa forma, algumas pragas ditas como secundárias, e até mesmo inexistentes, passaram a ser responsáveis por grandes prejuízos. O objetivo desse trabalho foi avaliar a aplicação de inseticida em diferentes velocidades (5 e 16 km h-1) variando as taxas da aplicação entre 108 a 110 e 199 a 216 L ha-1 para quantificar a diferença na porcentagem de cobertura do inseticida aplicado no dossel de plantas de soja e verificar a influência desses fatores em parâmetros de eficácia para o controle das lagartas (Helicoverpa armigera e Chrysodeixis includens). De modo geral, a maior cobertura foliar pelo inseticida foi observada no terço superior do dossel, independente da taxa e velocidade de aplicação, refletindo em menores injúrias foliares. Para os terços médio e inferior, a diminuição da velocidade teve mais influência na diminuição do dano foliar do que o aumento do volume.

ABSTRACT During the chemical control of pests, diseases and weeds, great importance is given to the phytosanitary product and little attention to the application technology. The control of soybean pests did not escape the general rule and, therefore, some pests known as secondary, and even nonexistent, became responsible for great damage to the soybean crop. The objective of this work was to test the application of insecticide at different speeds (5 and 16 km h-1) by varying the rates of application in 108 to 110 and 199 to 216 L ha-1 to quantify the difference in the coverage percentage of the applied insecticide in the canopy of soybean plants, and to verify the interaction of these factors with efficacy parameters for the control of caterpillars (Helicoverpa armigera and Chrysodeixis includens). In general, the highest leaf coverage by the insecticide was observed in the upper part of the canopy, regardless of the rate and speed of application, resulting in lower leaf damage. For the middle and lower thirds of the plant, the decrease in speed influenced more the decrease in leaf damage by the caterpillars than the increase in the spray volume.

Howard, 1988 Howard, 2004

This paper aims to access the best alternative, from a set of five, of software for statistical analysis in a seed company in Brazil. The methodology considers the costs related to the process, R programming and its relationship with the final decision made regarding the software selection, being all these aspects framed by the tool discussed in (Howard, 1988; Howard, 2004) applied to the information technology context. The results present cost reduction in the process of statistical analysis and a change in the decision about the statistical software to be used by the enterprise. The paper consider only one specific application of analysis used by the enterprise which can be improved with the use of platforms such as Rstudio, and the packages Knitr and Shiny.